Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation.

@article{Cuzzocrea2002PyrrolidineDA,
  title={Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation.},
  author={Salvatore Cuzzocrea and Prabal Kumar Chatterjee and Emanuela Mazzon and Laura Dugo and Ivana Serraino and Domenico Britti and Giuseppe Mazzullo and Achille Patrizio Caputi and Christoph Thiemermann},
  journal={British journal of pharmacology},
  year={2002},
  volume={135 2},
  pages={496-510}
}
The nuclear factor-kappaB (NF-kappaB) is a transcription factor which plays a pivotal role in the induction of genes involved in physiological processes as well as in the response to injury and inflammation. Dithiocarbamates are antioxidants which are potent inhibitors of NF-kappaB. We postulated that pyrrolidine dithiocarbamate (PDTC) would attenuate inflammation. In the present study we investigate the effects of PDTC in animal models of acute and chronic inflammation (carrageenan-induced… CONTINUE READING

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