Pyrrolidine Dithiocarbamate (PDTC) Attenuates Luteolin-Induced Apoptosis in Human Leukemia HL-60 Cells

@article{Lee2012PyrrolidineD,
  title={Pyrrolidine Dithiocarbamate (PDTC) Attenuates Luteolin-Induced Apoptosis in Human Leukemia HL-60 Cells},
  author={Ming-Fen Lee and Cheng-Ta Li and Ming-Dian Chen and An-Chin Cheng},
  journal={Journal of Cancer Therapy},
  year={2012},
  volume={3},
  pages={1125-1131}
}
Studies have indicated that flavonoid luteolin is a potential inhibitor of tumor cell proliferation and may function as an anticarcinogenic agent. Pyrrolidine dithiocarbamate (PDTC), a synthetic compound, may exhibit biphasic effects on apoptosis depending on the experimental context. Previously, we found that luteolin induced the activation of the proapoptotic proteins, such as Bad, Bid, and Bax, in HL-60 human leukemia cells. We also explored the modulatory effects and molecular mechanisms of… Expand

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References

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TLDR
It is found that pyrrolidine dithiocarbamate was able to inhibit luteolin-induced cell apoptosis in a dose-dependent manner and phosphorylation of Akt and caspase-9 by survival signals might play an important role in the ultimate fate of HL-60 cells. Expand
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TLDR
In vitro incubation of purified mitochondria with PDTC demonstrated that the molecule is directly able to induce cytochrome c release from the intermembrane space, thus confirming that mitochondria are a primary cellular target of the molecule. Expand
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TLDR
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TLDR
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