Pyrosequencing Unveils Cystic Fibrosis Lung Microbiome Differences Associated with a Severe Lung Function Decline.

  title={Pyrosequencing Unveils Cystic Fibrosis Lung Microbiome Differences Associated with a Severe Lung Function Decline.},
  author={Giovanni Bacci and Patrizia Paganin and Loredana Lopez and Chiara Vanni and Claudia Dalmastri and Cristina Cantale and Loretta Daddiego and Gaetano Perrotta and Daniela Dolce and Patrizia Morelli and Vanessa Tuccio and Alessandra De Alessandri and Ersilia Vita Fiscarelli and Giovanni Taccetti and Vincenzina Lucidi and Annamaria Bevivino and Alessio Mengoni},
  journal={PloS one},
  volume={11 6},
Chronic airway infection is a hallmark feature of cystic fibrosis (CF) disease. In the present study, sputum samples from CF patients were collected and characterized by 16S rRNA gene-targeted approach, to assess how lung microbiota composition changes following a severe decline in lung function. In particular, we compared the airway microbiota of two groups of patients with CF, i.e. patients with a substantial decline in their lung function (SD) and patients with a stable lung function (S… CONTINUE READING


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