Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis?

@article{Abe2016PyroptosisAA,
  title={Pyroptosis as a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis?},
  author={Jun-ichi Abe and Craig N. Morrell},
  journal={Circulation research},
  year={2016},
  volume={118 10},
  pages={
          1457-60
        }
}
Pyroptosis is characterized by pore formation in the plasma membrane, cell swelling, and membrane disruption. These cellular events are also noted in necrosis, but not apoptosis, which is defined as a mode of regulated or programmed necrosis. Jorgensen et al have defined pyroptosis by the following 4 criteria: (1) programmed by an inflammatory caspase activation, (2) pore formation in the plasma membrane, (3) DNA damage with terminal deoxynucleotidyl transferase dUTP nick-end labeling… CONTINUE READING
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