Pyrophosphate and diphosphonates in skeletal metabolism. Physiological, clinical and therapeutic aspects.

@article{Russell1975PyrophosphateAD,
  title={Pyrophosphate and diphosphonates in skeletal metabolism. Physiological, clinical and therapeutic aspects.},
  author={R. Graham G. Russell and Herbert Andre Fleisch},
  journal={Clinical orthopaedics and related research},
  year={1975},
  volume={108},
  pages={241-63}
}
Pyrophosphate and diphosphonates produce striking results on calcium metabolism in experimental animals and man. Compounds containing P-O-P- bonds (e.g. inorganic pyrophosphate [PP-ii1 or P-C-P bonds (diphosponates) inhibit both the formation and dissolution of calcium phosphate crystals in vitro. PP-i may have a physiological function in regulating calcification and bone turnover, and obnormalities in its metabolism may occur in some human diseases notably hypophosphatasia and pseudogout… CONTINUE READING