Pyrones as bacterial signaling molecules.

  title={Pyrones as bacterial signaling molecules.},
  author={Alexander O. Brachmann and Sophie Brameyer and Darko Kresovic and Ivana Hitkova and Yannick Kopp and Christian Manske and Karin C. Schubert and Helge B Bode and Ralf Heermann},
  journal={Nature chemical biology},
  volume={9 9},
Bacteria communicate via small diffusible molecules and thereby mediate group-coordinated behavior, a process referred to as quorum sensing. The prototypical quorum sensing system found in Gram-negative bacteria consists of a LuxI-type autoinducer synthase that produces N-acyl homoserine lactones (AHLs) as signals and a LuxR-type receptor that detects the AHLs to control expression of specific genes. However, many proteobacteria have proteins with homology to LuxR receptors yet lack any cognate… CONTINUE READING
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