Pyrolysed 3D-Carbon Scaffolds Induce Spontaneous Differentiation of Human Neural Stem Cells and Facilitate Real-Time Dopamine Detection

@inproceedings{Amato2014Pyrolysed3S,
  title={Pyrolysed 3D-Carbon Scaffolds Induce Spontaneous Differentiation of Human Neural Stem Cells and Facilitate Real-Time Dopamine Detection},
  author={Letizia Amato and Arto Heiskanen and Claudia Caviglia and Fozia J Shah and Kinga Z{\'o}r and Maciej Skolimowski and Marc Madou and Letizia Gammelgaard and Rasmus Stampe Hansen and Emma Gonzalez Seiz and Milagros Guizado Ramos and Tania Ramos Moreno and Alberto Mart{\'i}nez-Serrano and Stephan Sylvest Keller and Jenny Emn{\'e}us},
  year={2014}
}
Structurally patterned pyrolysed three-dimensional carbon scaffolds (p3D-carbon) are fabricated and applied for differentiation of human neural stem cells (hNSCs) developed for cell replacement therapy and sensing of released dopamine. In the absence of differentiation factors (DF) the pyrolysed carbon material induces spontaneous hNSC differentiation into mature dopamine-producing neurons and the 3D-topography promotes neurite elongation. In the presence and absence of DF, approximate to 73-82… CONTINUE READING

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