Corpus ID: 46530211

Pyroglutamic acid : throwing light on a lightly studied metabolite

  title={Pyroglutamic acid : throwing light on a lightly studied metabolite},
  author={A. Kumar and A. K. Bachhawat},
  • A. Kumar, A. K. Bachhawat
  • Published 2012
  • Chemistry
  • Pyroglutamic acid or 5-oxoproline is the cyclic lactam of glutamic acid. Its presence in living cells has been reported from archaebacteria to humans, and its occurrence in living cells has been known for over a century. Despite its almost ubiquitous presence, the role of pyroglutamic acid in living cells is poorly understood. Pyroglutamic acid is found as an N-terminal modification in many neuronal peptides and hormones that also include the accumulating peptides in Alzheimer’s disease and… CONTINUE READING
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