Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

@article{Wirths2009PyroglutamateAP,
  title={Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases},
  author={Oliver Wirths and Tobias Bethge and Andrea Marcello and Anja Harmeier and Sadim Jawhar and Paul J. Lucassen and Gerhard Multhaup and David L. Brody and Thomas J Esparza and Martin Ingelsson and Hannu Kalimo and Lars Lannfelt and Thomas A. Bayer},
  journal={Journal of Neural Transmission},
  year={2009},
  volume={117},
  pages={85 - 96}
}
The presence of AβpE3 (N-terminal truncated Aβ starting with pyroglutamate) in Alzheimer’s disease (AD) has received considerable attention since the discovery that this peptide represents a dominant fraction of Aβ peptides in senile plaques of AD brains. This was later confirmed by other reports investigating AD and Down’s syndrome postmortem brain tissue. Importantly, AβpE3 has a higher aggregation propensity, and stability, and shows an increased toxicity compared to full-length Aβ. We have… CONTINUE READING

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