Pyrocincholic acid 3β-O-β-d-quinovopyranosyl-28-O-β-d-glucopyranoside suppresses adipogenesis and regulates lipid metabolism in 3T3-L1 adipocytes

@article{Peng2017PyrocincholicA3,
  title={Pyrocincholic acid 3$\beta$-O-$\beta$-d-quinovopyranosyl-28-O-$\beta$-d-glucopyranoside suppresses adipogenesis and regulates lipid metabolism in 3T3-L1 adipocytes},
  author={Li Peng and Yanting Lu and Yuhui Xu and Jing Hu and Fang Wang and Yumei Zhang and Wen-Yong Xiong},
  journal={Natural Products and Bioprospecting},
  year={2017},
  volume={7},
  pages={225 - 234}
}
Obesity is crucially involved in many metabolic diseases, such as type 2 diabetes, cardiovascular disease and cancer. Regulating the number or size of adipocytes has been suggested to be a potential treatment for obesity. In this study, we investigated the effect of pyrocincholic acid 3β-O-β-d-quinovopyranosyl-28-O-β-d-glucopyranoside (PAQG), a 27-nor-oleanolic acid saponin extracted from Metadina trichotoma, on adipogenesis and lipid metabolism in 3T3-L1 adipocytes. The 3T3-L1 pre-adipocytes… 
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The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.

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