Pyrithione Zn selectively inhibits hypoxia-inducible factor prolyl hydroxylase PHD3.

Abstract

Increasing evidence emphasizes the role of the hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) isoforms in regulating non-HIF substrates, but isoform selective PHD inhibitors under physiological conditions have not yet been reported. Here we have identified pyrithione Zn (PZ) as a potent, isoform-selective PHD3 inhibitor. The IC50 value of PZ was… (More)
DOI: 10.1016/j.bbrc.2016.02.115

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