Pyripyropenes , Novel ACATInhibitors Produced by Aspergillus fumigatus IV . Structure Elucidation of Pyripyropenes Mto

Six new pyripyropenes, Mto R, were isolated from the ethyl acetate extracts of the jar fermentation broth of Aspergillusfumigatus FO-1289-2501. Structural elucidation indicated that all the pyripyropenes have the samepyridino-a-pyrone sesquiterpene core as pyripyropenes A to L. Amongthem pyripyropene Mshowed the most potent inhibition against acyl-CoA… (More)