Pyrimidine metabolism in Trichomonas vaginalis.

  title={Pyrimidine metabolism in Trichomonas vaginalis.},
  author={Paul G. Heyworth and W. E. Gutteridge and Colin Ginger},
  journal={FEBS letters},
  volume={176 1},
Pyrimidine metabolism in Trichomonas vaginalis was investigated using washed cell suspensions of the organism with radiolabelled pyrimidine ring precursors and preformed pyrimidines. The precursors [14C]orotate, [14C]bicarbonate and [14C]aspartate were not incorporated into the pyrimidine bases of trichomonal nucleic acids, indicating that the protozoan is unable to synthesise the pyrimidine ring and is dependent on the salvage of exogenous pyrimidines. [3H]uracil, [3H]uridine, [3H]cytidine… CONTINUE READING


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