Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase.

@article{Niedzwicki1981PyrimidineAI,
  title={Pyrimidine acyclonucleosides, inhibitors of uridine phosphorylase.},
  author={J G Niedzwicki and Mahmoud H. el Kouni and Shih Hsi Chu and Sungman Cha},
  journal={Biochemical pharmacology},
  year={1981},
  volume={30 15},
  pages={
          2097-101
        }
}
Effects of pyrimidine nucleoside phosphorylase inhibitors on hepatic fluoropyrimidine elimination in the rat.
TLDR
It was concluded that the hepatic elimination of FdUrd is slowed by pyrimidine nucleoside phosphorylase inhibitors and that some of these drugs block FUra, as well as Fd Urd, elimination.
Hepatic Fluoropyrimidine Elimination in the Rat Effects of Pyrimidine Nucleoside Phosphorylase Inhibitors on Updated
TLDR
It was concluded that the hepatic elimination of FdUrd is slowed by pyrimidine nucleoside phosphorylase inhibitors and that some of these drugs block FUra, as well as Fd Urd, elimination.
Uridine phosphorylase from Hymenolepis diminuta (Cestoda): kinetics and inhibition by pyrimidine nucleoside analogs.
A single pyrimidine nucleoside phosphorylase was found in the cytoplasmic extract from Hymenolepis diminuta. This enzyme preferentially cleaves uridine and, to a much lesser extent, thymidine. Its
5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase.
Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor.
  • G. Pizzorno, L. Yee, P. Calabresi
  • Biology, Chemistry
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1998
TLDR
On the basis of this clinical study, the suggested Phase II starting dose of BAU in combination with 5-FU is 800 mg/m2 and studies combining BAU with5-FU and incorporating appropriate molecular and biochemical end points to assess the effects of this drug combination on tumor and/or surrogate tumor tissue are under way.
...
...

References

SHOWING 1-10 OF 15 REFERENCES
Specificity of pyrimidine nucleoside phosphorylases and the phosphorolysis of 5-fluoro-2'-deoxyuridine.
TLDR
It is concluded that FdUrd is cleaved to 5-fluorouracil by uridine-deoxyuridine phosphorylase activity in Ehrlich ascites cells and in Novikoff hepatoma cells, and by dThdosphorylases in mouse liver, in normal human leukocytes, and in HeLa (S3) cells.
DEOXYRIBOSYL TRANSFER. I. THYMIDINE PHOSPHORYLASE AND NUCLEOSIDE DEOXYRIBOSYLTRANSFERASE IN NORMAL AND MALIGNANT TISSUES.
TLDR
Transferase activity was demonstrated in normal rat liver but not in the Novikoff hepatoma or a number of other rat tissues, and the absence of Reaction 2, catalyzed by the transferase, was not expected since reversal of phosphorolysis should theoretically result in equilibration between the labeled pyrimidine base and the pyridine of the nucleoside.
SPECIFICITY OF MOUSE URIDINE PHOSPHORYLASE. CHROMATOGRAPHY, PURIFICATION, AND PROPERTIES.
TLDR
This investigation provides evidence in support of three hypotheses explaining the pyrimidine deoxyribonucleoside phosphorolytic activity of mammalian uridine phosphorylase preparations: contamination by thymidine phosphate, contamination by a distinct enzyme, deoxyuridine phosphORYlase, and nonspecificity of some mammalian uridines for the pentose moiety, in contrast to an analogous bacterial enzyme.
A REVIEW OF SOME ASPECTS OF 5-IODODEOXYURIDINE AND AZAURIDINE.
TLDR
Although the role of IUDR as a chemotherapeutic agent in the treatment of neoplasms, either alone or in combination with other compounds or radiation, is still under investigation, its role as an anti-viral agent in some established DNA- viral infections in animals as well as in man has been well substantiated.
Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemia cells.
TLDR
The activity of all enzymes were quantitatively the same for the normal and CLL cells but severalfold higher activities were found for enzymes present in lymphoblasts from patients with acute lymphocytic leukemia.
...
...