Pyrimidine-Pyrazole Hybrids as Morpholinopyrimidine-Based Pyrazole Carboxamides: Synthesis, Characterisation, Docking, ADMET Study and Biological Evaluation

@article{Vekariya2018PyrimidinePyrazoleHA,
  title={Pyrimidine-Pyrazole Hybrids as Morpholinopyrimidine-Based Pyrazole Carboxamides: Synthesis, Characterisation, Docking, ADMET Study and Biological Evaluation},
  author={Mayur K. Vekariya and Rajesh H. Vekariya and Kinjal D. Patel and Nirav P. Raval and Prapti U. Shah and Dhanji P. Rajani and Nisha K Shah},
  journal={ChemistrySelect},
  year={2018}
}
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9 Citations

9 Citations

Citation Type

Citation Type

A Retrospective Study of Synthesis, Structure-Activity Relationship and Antimicrobial Activity of 4-Formyl Pyrazole Containing Isoniazid Moiety
4-Formyl pyrazole is nitrogen containing heterocyclic aromatic molecule containing isoniazid moiety. The molecule is formed by fusion of two heterocyclic ring i.e. pyrazole and isoniazid. The current…
Pyrazole Bearing Pyrimidine Analogues as the Privileged Scaffolds in Antimicrobial Drug Discovery: A Review
Abstract Historically, heterocyclic compounds including N-heterocycles and their derivatives are valuable source for the identification of therapeutically active agents. Studies in the recent two…
Recent advancements and developments in search of anti-tuberculosis agents: A quinquennial update and future directions
Molecular Docking and Three‐Dimensional Quantitative Structure–Activity Relationships for Antitubercular Pyrimidine Derivatives
Recent advances in development of anthelmintic agents: Synthesis and biological screening
TLDR
This review is primarily addressed to the description of the recent advances in the synthesis of heterocyclic compounds as anthelmintic agents, which can facilitate the development of more potent and effective anthel mintic agents.
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Novel N-thioamide analogues of pyrazolylpyrimidine based piperazine: Design, synthesis, characterization, in-silico molecular docking study and biological evaluation
Recent developments in synthetic chemistry and biological activities of pyrazole derivatives
TLDR
This systematic review covers the published studies from 1990 to date and provides an overview on the recent advances in synthetic approaches for the preparation of pyrazoles, including eco-friendly methodologies, heterogeneous catalytic systems, ligand-free systems, ultrasound and microwave-assisted reactions.
Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid–pyrimidine conjugates
TLDR
Investigation of a new series of isoniazid–pyrimidine conjugates synthesized in good yields and evaluated for antitubercular activity against the H37Rv strain of Mycobacterium tuberculosis suggests a rationale for further work on this promising series of antitubercles.

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