Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms

Abstract

BACKGROUND African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite. METHODOLOGY/PRINCIPAL FINDINGS Pyrimidine requirements for growth were investigated using strictly pyrimidine-free media, with or without single added… (More)
DOI: 10.1371/journal.pone.0058034

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