Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.

  title={Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.},
  author={L A Peterson and X K Liu and Stephen S Hecht},
  journal={Cancer research},
  volume={53 12},
The carcinogenic tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), both methylates and pyridyloxobutylates DNA. O6-Methylguanine (O6-mG) persistence has been correlated to NNK-induced lung tumor formation in A/J mice. The pyridyloxobutylation pathway enhances the tumorigenicity of the methylation pathway. In this paper we test the hypothesis that DNA pyridyloxobutylation increases O6-mG persistence by inhibiting the repair protein O6-alkylguanine-DNA… CONTINUE READING