Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography

  title={Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography},
  author={Per Hartvig and K. J. Lindner and Peter Bjurling and Bengt L{\aa}ngstr{\"o}m and Joakim Tedroff},
  journal={Journal of Neural Transmission / General Section JNT},
The influence of the co-factor pyridoxine, vitamin B6, on the activity of aromatic amino acid decarboxylase enzyme was studied by positron emission tomography, PET in the brain of the Rhesus monkey using the precursor for serotonin synthesis 5-hydroxy-L-tryptophan (5-HTP) radiola-belled with11C in the β-position. The rate constant for the formation of serotonin in the corpus striatum was calculated using a two tissue compartment model with reference area in the brain. In baseline investigations… 
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