Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography

@article{Hartvig2005PyridoxineEO,
  title={Pyridoxine effect on synthesis rate of serotonin in the monkey brain measured with positron emission tomography},
  author={Per Hartvig and K. J. Lindner and Peter Bjurling and Bengt L{\aa}ngstr{\"o}m and Joakim Tedroff},
  journal={Journal of Neural Transmission / General Section JNT},
  year={2005},
  volume={102},
  pages={91-97}
}
The influence of the co-factor pyridoxine, vitamin B6, on the activity of aromatic amino acid decarboxylase enzyme was studied by positron emission tomography, PET in the brain of the Rhesus monkey using the precursor for serotonin synthesis 5-hydroxy-L-tryptophan (5-HTP) radiola-belled with11C in the β-position. The rate constant for the formation of serotonin in the corpus striatum was calculated using a two tissue compartment model with reference area in the brain. In baseline investigations… 
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39 Citations

An Overview of PET Studies of the Cerebral Uptake of Amino Acids
TLDR
The trapping of [18F]-fluorodopa (FDOPA) and other aromatic L-amino acid decarboxylase (AAADC) substrates reveals the integrity of the nigrostriatal dopamine pathway, without interference from a background of physiological protein synthesis.
Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications
TLDR
In conclusion, PET with radiolabelled substrates for the serotonergic pathway is the only direct way to detect changes of serotonin synthesis in the living brain.
Validation studies on the 5‐hydroxy‐L‐[β‐11C]‐tryptophan/PET method for probing the decarboxylase step in serotonin synthesis
TLDR
It is demonstrated that the 2TCM for [11C]HTP/PET is able to detect changes occurring during alteration of the biological process (i.e., the conversion of HTP to serotonin), which may be considered negligible if the PET study is limited to 60 min.
5‐HT radioligands for human brain imaging with PET and SPECT
TLDR
The development of PET and SPECT radioligands to image serotonergic targets is of high interest, and successful evaluation in humans is leading to invaluable insight into normal and abnormal brain function, emphasizing the need for continued development of both SPECT and PET radiolIGands for human brain imaging.
Areal and subcellular localization of the ubiquitous alkaline phosphatase in the primate cerebral cortex: evidence for a role in neurotransmission.
The ubiquitous enzyme TNAP (tissue non-specific alkaline phosphatase) is found in numerous tissues such as liver, kidney and bone, but little attention has been paid to its expression and role in the…
Layer-specific activity of tissue non-specific alkaline phosphatase in the human neocortex
Interaction between dietary tryptophan and pyridoxine on tryptophan metabolism, immune responses and
Synergistic antinociceptive interaction between acetaminophen or metamizol and B vitamins in the formalin test
TLDR
Isobolographic analyses revealed that both acetaminophen or metamizol and the B vitamins mixture interacted synergistically in the formalin test, suggesting that these two combinations could be useful in treating inflammatory pain states.
Thiamine and Cyanocobalamin Relieve Neuropathic Pain in Rats: Synergy with Dexamethasone
TLDR
It is suggested that thiamine and pyridoxine as well as the combination of B vitamins and dexamethasone are able to reduce tactile allodynia in rats and suggest the possible clinical use of these drugs in the treatment of neuropathic pain in human beings.
Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep
TLDR
It was found that vitamin B6 significantly increased the amount of dream content participants recalled but did not significantly affect dream vividness, bizarreness, or color, nor did it significantly affect other sleep-related variables.
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