Pyridoxine (vitamin B6) neurotoxicity: enhancement by protein‐deficient diet

@article{Levine2004PyridoxineB,
  title={Pyridoxine (vitamin B6) neurotoxicity: enhancement by protein‐deficient diet},
  author={Seymour Levine and Arthur M. Saltzman},
  journal={Journal of Applied Toxicology},
  year={2004},
  volume={24}
}
Large doses of pyridoxine cause injury to the primary sensory neurons in trigeminal and dorsal root ganglia of animals and patients subjected to megavitamin therapy. The increased hazard to subjects with reduced renal excretory function has been explored previously. In the present work, the neurotoxicity of pyridoxine for rats was found to be increased by dietary protein deficiency. A mere 3 or 7 days of pretreatment with either of two protein‐deficient diets were sufficient to accelerate and… 

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