Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations.

@article{Eliot2004PyridoxalPE,
  title={Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations.},
  author={Andrew C Eliot and J. Kirsch},
  journal={Annual review of biochemistry},
  year={2004},
  volume={73},
  pages={
          383-415
        }
}
Pyridoxal phosphate (PLP)-dependent enzymes are unrivaled in the diversity of reactions that they catalyze. New structural data have paved the way for targeted mutagenesis and mechanistic studies and have provided a framework for interpretation of those results. Together, these complementary approaches yield new insight into function, particularly in understanding the origins of substrate and reaction type specificity. The combination of new sequences and structures enables better… Expand
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