Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations.

@article{Eliot2004PyridoxalPE,
  title={Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations.},
  author={A. C. Eliot and J. Kirsch},
  journal={Annual review of biochemistry},
  year={2004},
  volume={73},
  pages={
          383-415
        }
}
Pyridoxal phosphate (PLP)-dependent enzymes are unrivaled in the diversity of reactions that they catalyze. New structural data have paved the way for targeted mutagenesis and mechanistic studies and have provided a framework for interpretation of those results. Together, these complementary approaches yield new insight into function, particularly in understanding the origins of substrate and reaction type specificity. The combination of new sequences and structures enables better… Expand
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      References

      SHOWING 1-10 OF 108 REFERENCES
      Pyridoxal enzymes: mechanistic diversity and uniformity.
      • H. Hayashi
      • Chemistry, Medicine
      • Journal of biochemistry
      • 1995
      • 141
      The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes.
      • 223
      Evolutionary relationships among pyridoxal‐5′‐phosphate‐dependent enzymes
      • 307
      Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase.
      • 136
      Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes.
      • 31
      Stereospecificity for the hydrogen transfer of pyridoxal enzyme reactions.
      • 41
      Pyridoxal 5'-phosphate-dependent alpha,beta-elimination reactions: mechanism of O-acetylserine sulfhydrylase.
      • C. Tai, P. Cook
      • Chemistry, Medicine
      • Accounts of chemical research
      • 2001
      • 44
      Molecular organization, catalytic mechanism and function of serine hydroxymethyltransferase--a potential target for cancer chemotherapy.
      • 36
      Formation of unusual sugars: mechanistic studies and biosynthetic applications.
      • 123
      Mechanism-based inactivation of bacterial kynureninase by beta-substituted amino acids.
      • G. Kishore
      • Medicine, Chemistry
      • The Journal of biological chemistry
      • 1984
      • 20
      ...
      1
      2
      3
      4
      5
      ...