Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products.

@article{Du2018PyridoxalPR,
  title={Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products.},
  author={Yi-Ling Du and Katherine S Ryan},
  journal={Natural product reports},
  year={2018}
}
Covering: up to mid-2018Pyridoxal 5'-phosphate (PLP) is a versatile organic cofactor used to catalyze diverse reactions on amino acid, oxoacid, and amine substrates. Here we review the reactions catalyzed by PLP-dependent enzymes, highlighting enzymes reported in the natural product biosynthetic literature. We describe enzymes that catalyze transaminations, Claisen-like condensations, and β- and γ-eliminations and substitutions, along with epimerizations, decarboxylations, and transaldolations… CONTINUE READING
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