Pyridostigmine reduces QTc interval during recovery from maximal exercise in ischemic heart disease.

@article{Castro2006PyridostigmineRQ,
  title={Pyridostigmine reduces QTc interval during recovery from maximal exercise in ischemic heart disease.},
  author={Renata R T Castro and Salvador Manoel Serra and Graciema Porphirio and Fernanda de Souza Nogueira Sardinha Mendes and Leonardo Pires Oliveira and Antonio C L N{\'o}brega},
  journal={International journal of cardiology},
  year={2006},
  volume={107 1},
  pages={138-9}
}
Following a randomized, cross-over, and double-blind design, 14 patients with coronary heart disease were submitted, to maximal cardiopulmonary exercise tests on a treadmill, 2 h after the oral administration of either placebo or pyridostigmine bromide (45 mg), a reversible cholinesterase inhibitor. One observer, who was blind to the experimental condition, measured RR and QT intervals over the 12 electrocardiographic leads in the first and third minute of active recovery from exercise. Paired… CONTINUE READING