Pyridostigmine in the Treatment of Postural Orthostatic Tachycardia: A Single‐Center Experience

@article{Kanjwal2011PyridostigmineIT,
  title={Pyridostigmine in the Treatment of Postural Orthostatic Tachycardia: A Single‐Center Experience},
  author={Khalil Kanjwal and Beverly L. Karabin and Mujeeb Abdul Sheikh and Lawrence W. Elmer and Yousuf Kanjwal and Bilal Saeed and Blair P Grubb},
  journal={Pacing and Clinical Electrophysiology},
  year={2011},
  volume={34}
}
Background:  The long‐term efficacy of pyridostigmine, a reversible acetyl cholinesterase inhibitor, in the treatment of postural orthostatic tachycardia syndrome (POTS) patients remains unclear. We report our retrospective, single‐center, long‐term experience regarding the efficacy and adverse effect profile of pyridostigmine in the treatment of POTS patients. 

Acute Water Ingestion as a Treatment for Postural Orthostatic Tachycardia Syndrome

A novel approach to acute treatment for POTS is discussed, which was able to replicate her symptoms, which were due to tachycardia in a standing position that resolved upon sitting, after being offered eight ounces (236.6 mL) of water and, after consumption of such, the standing tachycardsia was no longer observed.

Diagnosis and management of postural orthostatic tachycardia syndrome: A brief review

This syndrome appears to describe a group of conditions with differing pathophysiology, which requires treatment tailored to the true underlying disorder, which needs to be fully evaluated to guide treatment.

Postural orthostatic tachycardia syndrome (POTS) occurring during treatment for breast cancer

A case of a middle-aged woman presenting with a new onset of POTS likely due to chemotherapy for treatment of breast cancer is reported, to encourage clinicians to consider POTS as a differential diagnosis, while managing patients with symptoms of orthostatic intolerance.

Postural tachycardia syndrome: current perspectives

The factors and mechanisms that may contribute to the symptoms and signs of POTS are reviewed and the perspectives on the clinical approach toward the diagnosis and management of this complex syndrome are presented.

Evaluating and managing postural tachycardia syndrome

Postural tachycardia syndrome (POTS) is a disorder of the autonomic nervous system with many possible causes, characterized by an unexplained increase in heartbeat without change in blood pressure

Postural Orthostatic Tachycardia Syndrome

This review details the most current views on the potential causes, comorbid conditions, proposed subtypes, differential diagnoses, evaluations, and treatment of POTS from cardiological and neurological perspectives.

Postural Orthostatic Tachycardia Syndrome (POTS): Evaluation and Management

A 29 year-old woman had been well until 7 months previously when, after a viral syndrome, she developed palpitations, fatigue, and frequent episodes of light headedness and near syncope. On further

Diagnosis and management of postural orthostatic tachycardia syndrome

The diagnosis of POTS, conditions to consider in the differential diagnosis, associated disorders and the pharmacologic and nonpharmacologic management of patients with POTS are discussed, based on original research, narrative reviews and consensus statements.
...

References

SHOWING 1-10 OF 11 REFERENCES

Pyridostigmine for treatment of neurogenic orthostatic hypotension [correction of hypertension]--a follow-up survey study.

The result of a follow-up, open-label study of pyridostigmine for treatment of orthostatic hypotension was that most patients were very satisfied with the medication and chose to continue it.

Pyridostigmine for treatment of neurogenic orthostatic hypertension

A follow-up, open-label study of pyridostigmine for treatment of orthostatic hypotension evaluated self-reported efficacy and patients’ satisfaction with the medication.

The Postural Tachycardia Syndrome: A Concise Guide to Diagnosis and Management

The aim of this brief report is to outline the clinical picture, subtypes, diagnosis, and management of POTS.

Pyridostigmine in the Treatment of Orthostatic Intolerance

Long-term data are insufficient to support recommending the routine use of pyridostigmine bromide for treatment of orthostatic intolerance, and modest but statistically significant improvements in hemodynamic measurements are found.

[Pyridostigmine in the treatment of primary orthostatic hypotension].

Pyridostigmine seems to be as useful as fludrocortisone in the POH treatment and has less side effects, and may be an alternative or a complement in the treatment of the illness.

Pyridostigmine treatment trial in neurogenic orthostatic hypotension.

Pyridostigmine significantly improves standing BP in patients with OH without worsening supine hypertension, suggesting that the improvement is due to increased total peripheral resistance.

Acetylcholinesterase Inhibition Improves Tachycardia in Postural Tachycardia Syndrome

Acute acetylcholinesterase inhibition significantly attenuated tachycardia in POTS and there was also an improvement in symptom burden with this promising therapy.

The Postural Orthostatic Tachycardia Syndrome:

This article presents a review of the pathophysiology, diagnosis, and management of this disorder, generally known as the postural orthostatic tachycardia syndrome (POTS), which has seen a tremendous expansion in knowledge over the last two decades.

Orthostatic Hypotension:

The importance of otiological diagnosis, the use of objoc-tive tests, and appropcinto therapy, especially concerning the organic forms, is considered.

Tratamiento de la hipotensión ortostática primaria con piridostigmina

Pyridostigmine seems to be as useful as fludrocortisone in the POH treatment and has less side effects, and this new strategy may be an alternative or a complement in the treatment of the illness.