Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.

@article{Pedranzini2006Pyridone6A,
  title={Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.},
  author={Laura Pedranzini and Tobias Dechow and Marjan Berishaj and Raymond L. Comenzo and Ping Zhou and Janeen Azare and William G. B. Bornmann and Jacqueline Bromberg},
  journal={Cancer research},
  year={2006},
  volume={66 19},
  pages={9714-21}
}
Interleukin-6 (IL-6) and the subsequent Janus-activated kinase (JAK)-dependent signaling pathways play a critical role in the pathogenesis of multiple myeloma. Here, we compared the sensitivity and specificity of a novel pan-JAK inhibitor, tetracyclic pyridone 6 (P6), with that of AG490 in a panel of myeloma-derived cell lines. P6 induced growth arrest and… CONTINUE READING