Pyridine nucleotide synthesis in human blood--effect of leucine, alpha-ketoisocaproic acid and ketone bodies.

@article{Yamada1983PyridineNS,
  title={Pyridine nucleotide synthesis in human blood--effect of leucine, alpha-ketoisocaproic acid and ketone bodies.},
  author={O. Yamada and Yoshifumi Kiyohara and Kazumi Sano and Chisae Y. Umezawa},
  journal={International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition},
  year={1983},
  volume={53 4},
  pages={
          432-7
        }
}
The effects of L-leucine and its metabolites on pyridine nucleotide synthesis were investigated in human blood. After 30 min-incubation 40% of the added (carboxyl-14C)-nicotinic acid was incorporated into pyridine nucleotides, most of which was nicotinic acid mononucleotide. Leucine and alpha-ketoisocaproic acid reduced pyridine nucleotide synthesis by 40% and 15%, respectively at 1 mM level. Ketone bodies were without effect. The results were different from those observed in rat hepatocytes [O… CONTINUE READING