Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.

Abstract

Incorporation of pyridines and diazines into the biphenyl region of quinolone carboxylic acid derived M(1) positive allosteric modulators was investigated as a means of lowering plasma protein binding to enhance CNS exposure.

DOI: 10.1016/j.bmcl.2009.11.059

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@article{Kuduk2010PyridineCM, title={Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.}, author={Scott D. Kuduk and Christina Ng Di Marco and Victoria Cofre and Daniel R Pitts and William J. Ray and Lei Ma and Marion Wittmann and Matthew A. Seager and Kenneth Alan Koeplinger and Chuck D Thompson and George D. Hartman and Mark T Bilodeau}, journal={Bioorganic & medicinal chemistry letters}, year={2010}, volume={20 2}, pages={657-61} }