Synthesis and biological evaluation of new 3-(4-substituted phenyl)aminoquinoxaline derivatives as anticancer agents
- GT Mohamed, AAEB Serry, NAN Magda
- Heterocycl Commun
Quinoxaline derivatized with coumarin viz., 3a–f and with sydnones viz., 7a–0 were synthesized using pyridine as catalyst. Among the coumarin derivatives, 3a and 3b have been screened for anticancer activity against 60 human cancer cell lines at NIH (USA). Compound 3a has shown 55.75 % GI against Melanoma (MALME-M) tumor cell line. Further, the sydnone derivatives 7d–i inhibited the Mycobacterium tuberculae H37RV.