Pyridine-catalyzed synthesis of quinoxalines as anticancer and anti-tubercular agents

Abstract

Quinoxaline derivatized with coumarin viz., 3a–f and with sydnones viz., 7a–0 were synthesized using pyridine as catalyst. Among the coumarin derivatives, 3a and 3b have been screened for anticancer activity against 60 human cancer cell lines at NIH (USA). Compound 3a has shown 55.75 % GI against Melanoma (MALME-M) tumor cell line. Further, the sydnone derivatives 7d–i inhibited the Mycobacterium tuberculae H37RV.

DOI: 10.1007/s00044-016-1558-2

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@article{Kamble2016PyridinecatalyzedSO, title={Pyridine-catalyzed synthesis of quinoxalines as anticancer and anti-tubercular agents}, author={Atulkumar A. Kamble and Ravindra Ramappa Kamble and Mahadev N. Kumbar and Gireesh Tegginamath}, journal={Medicinal Chemistry Research}, year={2016}, volume={25}, pages={1163-1174} }