Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis.

@article{Nam2009PyridineAP,
  title={Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis.},
  author={Tae-gyu Nam and Susheel J. Nara and Ir{\`e}ne Zagol-Ikapitte and Thomas Cooper and Luca Valgimigli and John A. Oates and Ned A. Porter and Olivier Boutaud and Derek A Pratt},
  journal={Organic & biomolecular chemistry},
  year={2009},
  volume={7 24},
  pages={5103-12}
}
Herein we report an investigation of the efficacy of pyridine and pyrimidine analogs of acetaminophen (ApAP) as peroxyl radical-trapping antioxidants and inhibitors of enzyme-catalyzed lipid peroxidation by cyclooxygenases (COX) and lipoxygenases (LOX). In inhibited autoxidations we find that ApAP, the common analgesic and antipyretic agent, is a very good antioxidant with a rate constant for reaction with peroxyl radicals (k(inh) = 5 x 10(5) M(-1) s(-1)) that is higher than many widely-used… CONTINUE READING
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