Pyretic action of low doses of gamma-hydroxybutyrate in rats.


gamma-Hydroxybutyrate (GHB) has been found to have a biphasic effect on body temperature with increased body temperature after low doses (5-10 mg/kg) and decreased body temperature after high doses (300-500 mg/kg). Brain levels of GHB between 30 and 60 min post-injection of GHB were not altered by the low doses (5-10 mg/kg), although a dose of 200 mg/kg produced a large increase in the brain concentration.


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@article{Kaufman1990PyreticAO, title={Pyretic action of low doses of gamma-hydroxybutyrate in rats.}, author={Elaine E. Kaufman and Linda J. Porrino and Tasha Nelson}, journal={Biochemical pharmacology}, year={1990}, volume={40 12}, pages={2637-40} }