Pyrene acts as a cocarcinogen with the carcinogens benzo [a] pyrene, β-propiolactone and radiation in the induction of malignant transformation in cultured mouse fibroblasts; soybean extract containing the Bowman-Birk inhibitor acts as an anticarcinogen

@article{Baturay1986PyreneAA,
  title={Pyrene acts as a cocarcinogen with the carcinogens benzo [a] pyrene, β-propiolactone and radiation in the induction of malignant transformation in cultured mouse fibroblasts; soybean extract containing the Bowman-Birk inhibitor acts as an anticarcinogen},
  author={Nesrine Baturay and Ann R. Kennedy},
  journal={Cell Biology and Toxicology},
  year={1986},
  volume={2},
  pages={21-32}
}
Pyrene was found to act as a cocarcinogen in the induction of transformation of cultured Balb/c3T3 cells by three different types of carcinogens: a direct acting chemical carcinogen, β-propiolactone, a chemical carcinogen requiring metabolic activation, benzo[a]pyrene, and a physical carcinogen (60Co) gamma radiation. Since pyrene enhanced transformation in vitro by approximately the same amount for all the carcinogens tested, these results suggest that the carcinogenic action of pyrene is not… CONTINUE READING

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