Pyrazoline bisphosphonate esters as novel antiinflammatory and antiarthritic agents.

@article{Nugent1993PyrazolineBE,
  title={Pyrazoline bisphosphonate esters as novel antiinflammatory and antiarthritic agents.},
  author={Richard A Nugent and Megan Murphy and Stephen T Schlachter and Colin J. Dunn and Richard J. Smith and Nigel D. Staite and L A Galinet and S. K. Shields and Danielle G. Aspar and Kujat Richard},
  journal={Journal of medicinal chemistry},
  year={1993},
  volume={36 1},
  pages={134-9}
}
Vinylidenebisphosphonic acid tetraethyl ester (1) and diazo ketones 7a-1 in ether at 22 degrees C yield pyrazoline bisphosphonate tetraethyl esters 8a-1 in moderate to good yield. These compounds were evaluated in animal models of arthritis: rat adjuvant-induced polyarthritis (AIP) and murine antigen-induced arthritis (AIA) and a murine model of chronic… CONTINUE READING