Pyrazine functionalized Ag(I) and Au(I)-NHC complexes are potential antibacterial agents.

@article{Roymahapatra2012PyrazineFA,
  title={Pyrazine functionalized Ag(I) and Au(I)-NHC complexes are potential antibacterial agents.},
  author={Gourisankar Roymahapatra and Santi Mohan Mandal and William F. Porto and Tapastaru Samanta and Samir Giri and Joydev Dinda and Oct{\'a}vio Lu{\'i}s Franco and Pratim Kumar Chattaraj},
  journal={Current medicinal chemistry},
  year={2012},
  volume={19 24},
  pages={
          4184-93
        }
}
Antimicrobial resistance is an ever-increasing problem throughout the world and has already reached severe proportions. Bacteria can develop ways to render traditional antibiotics ineffective, raising a crucial need to find new antimicrobials with novel mode of action. We demonstrate here a novel class of pyrazine functionalized Ag(I) and Au(I)-NHC complexes as antibacterial agents against human pathogens that are resistant to several antibiotics. Complete synthetic and structural studies of Au… CONTINUE READING