Pyrazine derivatives affect membrane fluidity of vascular smooth muscle microsomes in relation to their biological activity.

@article{Nie1993PyrazineDA,
  title={Pyrazine derivatives affect membrane fluidity of vascular smooth muscle microsomes in relation to their biological activity.},
  author={S. Nie and C. Kwan and R. Epand},
  journal={European journal of pharmacology},
  year={1993},
  volume={244 1},
  pages={
          15-9
        }
}
  • S. Nie, C. Kwan, R. Epand
  • Published 1993
  • Chemistry, Medicine
  • European journal of pharmacology
    • We have previously demonstrated that several structurally similar pyrazine derivatives, tetramethylpyrazine (TMP), triethylpyrazine (3EP) and tetraethylpyrazine (TEP) consistently inhibited a wide spectrum of plasmalemma-associated biological activities of vascular smooth muscles in contractility and radioligand binding studies in the following order of increasing potency, TMP < 3EP < TEP. We speculated that these pyrazine derivatives elicit multiple effects in the above order of potency by… CONTINUE READING
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