Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1.

@article{Liu2013PyranoflavonesAG,
  title={Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1.},
  author={Jiawang Liu and Shannon F Taylor and Patrick S Dupart and Corey L Arnold and Jayalakshmi Sridhar and Quan Jiang and Yuji Wang and Elena V Skripnikova and Mingming Zhao and Maryam K. Foroozesh},
  journal={Journal of medicinal chemistry},
  year={2013},
  volume={56 10},
  pages={4082-92}
}
Selective inhibition of P450 enzymes is the key to block the conversion of environmental procarcinogens to their carcinogenic metabolites in both animals and humans. To discover highly potent and selective inhibitors of P450s 1A1, 1A2, and 1B1, as well as to investigate active site cavities of these enzymes, 14 novel flavone derivatives were prepared as chemical probes. Fluorimetric enzyme inhibition assays were used to determine the inhibitory activities of these probes toward P450s 1A1, 1A2… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 39 references

cytochrome p450 enzymes by quinones and anthraquinones

J. Liu, T. T. Nguyen, +3 authors Zhu
Chem. Res. Toxicol • 2012

inhibitors of human cytochrome P450s 1A1 and 1A2

J. Sridhar, P. Jin, J. Liu, M. Foroozesh, C. L. Stevens
Chem. Res. Toxicol • 2012

Similar Papers

Loading similar papers…