Pyramidal Neurons Grow Up and Change Their Mind

@article{Fishell2008PyramidalNG,
  title={Pyramidal Neurons Grow Up and Change Their Mind},
  author={Gord Fishell and Carina Hanashima},
  journal={Neuron},
  year={2008},
  volume={57},
  pages={333-338}
}
The precise stereotypic projections of pyramidal neurons within the six-layered cortex of mammals are key in allowing this structure to attain its high level of function. Recent studies have provided the first indications that postmitotic transcription factors are required for the formation and maintenance of both corticofugal and intracortical pyramidal cell populations. Here, we discuss these new findings in the context of our present understanding of cortical cell specification. 
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References

SHOWING 1-10 OF 65 REFERENCES
Neuronal subtype specification in the cerebral cortex
TLDR
Recent data regarding the nature of neocortical progenitors is assessed, the roles of individual genes in projection neuron specification are reviewed and the implications for progenitor plasticity are discussed. Expand
Experimental manipulation of cerebral cortical areas in primates.
  • P. Rakic
  • Biology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1991
TLDR
The protomap hypothesis suggests how the cytoarchitectonic pattern of the cerebral cortex may be generated by a combination of intrinsic and extrinsic influences during embryonic development. Expand
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
  • T. Jessell
  • Biology, Medicine
  • Nature Reviews Genetics
  • 2000
TLDR
The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules. Expand
Specification of cerebral cortical areas.
TLDR
The radial unit model provides a framework for understanding cerebral evolution, epigenetic regulation of the parcellation of cytoarchitectonic areas, and insight into the pathogenesis of certain cortical disorders in humans. Expand
Fezl Is Required for the Birth and Specification of Corticospinal Motor Neurons
TLDR
Data indicate that Fezl plays a central role in the specification of corticospinal motor neurons and other subcerebral projection neurons, controlling early decisions regarding lineage-specific differentiation from neural progenitors. Expand
Clonally related cortical cells show several migration patterns.
TLDR
This hypothesis that the cortex consists of radial, ontogenetic units of clonally related neurons was tested by studying cell lineage in the rat cortex with a retroviral vector carrying the Escherichia coli beta-galactosidase gene, which can be easily visualized. Expand
Hox Genes: The Instructors Working at Motor Pools
TLDR
A new study by Dasen et al. (2005) shows that a network of Hox genes is responsible for instructing motor pool development. Expand
Transcriptional codes and the control of neuronal identity.
TLDR
The actions of transcription factors within motor neuron progenitors, which initiate a cascade of transcriptional interactions that lead to motor neuron specification, are described and the downstream targets of the LIM code are discussed, especially in the context of subtype-specific motor axon pathfinding. Expand
Fates of visual cortical neurons in the ferret after isochronic and heterochronic transplantation
  • S. Mcconnell
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
TLDR
The experiments described here constitute an attempt to manipulate the fates of newly generated cortical neurons upon transplantation, with results that suggest the possibility that the commitment of a cell to a particular laminar position and set of connections may occur very early on in cortical development. Expand
Restriction of Late Cerebral Cortical Progenitors to an Upper-Layer Fate
TLDR
It is revealed that late cortical progenitors are not competent to generate deep-layer neurons and are instead restricted to producing the upper layers. Expand
...
1
2
3
4
5
...