Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections.

@article{Rada2013PyocyaninEO,
  title={Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections.},
  author={Bal{\'a}zs Rada and Thomas L. Leto},
  journal={Trends in microbiology},
  year={2013},
  volume={21 2},
  pages={73-81}
}
Pseudomonas aeruginosa (PA) uses several virulence factors to establish chronic respiratory infections in bronchiectasis, chronic obstructive pulmonary disease, and cystic fibrosis (CF) patients. One of its toxins, pyocyanin (PYO), is a redox-active pigment that is required for full virulence in animal models and has been detected in patients' airway secretions. PYO promotes virulence by interfering with several cellular functions in host cells including electron transport, cellular respiration… CONTINUE READING
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