Pyk2 promotes tumor progression in multiple myeloma.

  title={Pyk2 promotes tumor progression in multiple myeloma.},
  author={Yu Zhang and Michele Moschetta and Daisy Huynh and Yu-Tzu Tai and Yong Zhang and Wenjing Zhang and Yuji Mishima and Jennifer E. Ring and Winnie Tam and Qunli Xu and Patricia Maiso and Michaela R Reagan and Ilyas Sahin and Antonio Sacco and Salomon Manier and Yosra Aljawai and Siobhan V Glavey and Nikhil C. Munshi and Kenneth C. Anderson and Jonathan A. Pachter and Aldo M Roccaro and Irene M Ghobrial},
  volume={124 17},
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family that has been recently linked to tumor development. However, its role in modulating multiple myeloma (MM) biology and disease progression remains unexplored. We first demonstrated that patients with MM present with higher expression of Pyk2 compared with healthy individuals. By using loss-of-function approaches, we found that Pyk2 inhibition led to reduction of MM tumor growth in vivo as well as decreased cell… CONTINUE READING
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