Pyk2 and FAK differentially regulate progression of the cell cycle.

  title={Pyk2 and FAK differentially regulate progression of the cell cycle.},
  author={Jihe Zhao and Chuanhai Zheng and Jun-Lin Guan},
  journal={Journal of cell science},
  volume={113 ( Pt 17)},
We have previously identified FAK and its associated signaling pathways as a mediator of cell cycle progression by integrins. In this report, we have analyzed the potential role and mechanism of Pyk2, a tyrosine kinase closely related to FAK, in cell cycle regulation by using tetracycline-regulated expression system as well as chimeric molecules. We have found that induction of Pyk2 inhibited G(1) to S phase transition whereas comparable induction of FAK expression accelerated it. Furthermore… CONTINUE READING


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