Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis

@inproceedings{Chung2016Pyk2AT,
  title={Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis},
  author={I-Che Chung and Chun-Nan OuYang and Sheng-Ning Yuan and Hsin-Pai Li and Jeng-Ting Chen and H. -R. Shieh and Yu-Jen Chen and David M. Ojcius and Ching-Liang Chu and Jau-Song Yu and Yu-Sun Chang and Lih-Chyang Chen},
  booktitle={Scientific reports},
  year={2016}
}
The inflammasome adaptor protein, ASC, contributes to both innate immune responses and inflammatory diseases via self-oligomerization, which leads to the activation of the protease, caspase-1. Here, we report that the cytosolic tyrosine kinases, FAK and Pyk2, are differentially involved in NLRP3 and AIM2 inflammasome activation. The inhibition of FAK and Pyk2 with RNA interference or chemical inhibitors dramatically abolished ASC oligomerization, caspase-1 activation, and IL-1β secretion in… CONTINUE READING
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