PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

@article{Lim2008PyK2AF,
  title={PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility},
  author={Yangmi Lim and S Lim and Alok Tomar and Margaret L. Gardel and Joie A. Bernard-Trifilo and Xiao Chen and Sean A. Uryu and Rafaela Ca{\~n}ete-Soler and Jinbin Zhai and Hong Lin and William W. Schlaepfer and Perihan Nalbant and Gary M. Bokoch and Du{\vs}ko Ili{\'c} and Clare M. Waterman-Storer and David D. Schlaepfer},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={180},
  pages={187 - 203}
}
Integrin binding to matrix proteins such as fibronectin (FN) leads to formation of focal adhesion (FA) cellular contact sites that regulate migration. RhoA GTPases facilitate FA formation, yet FA-associated RhoA-specific guanine nucleotide exchange factors (GEFs) remain unknown. Here, we show that proline-rich kinase-2 (Pyk2) levels increase upon loss of… CONTINUE READING