Puupehanol, a sesquiterpene-dihydroquinone derivative from the marine sponge Hyrtios sp.

@article{Xu2009PuupehanolAS,
  title={Puupehanol, a sesquiterpene-dihydroquinone derivative from the marine sponge Hyrtios sp.},
  author={Wen-Hui Xu and Yuanqing Ding and Melissa Ruth Jacob and Ameeta Kishore Agarwal and Alice Mae Clark and Daneel Ferreira and Zongsuo Liang and X A Li},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 21},
  pages={6140-3}
}
Puupehanol (1), a new sesquiterpene-dihydroquinone derivative, was isolated from the marine sponge Hyrtios sp., along with the known compounds puupehenone (2) and chloropuupehenone (3) that are responsible for the antifungal activity observed in the extract. The structure of 1 was established as (20R,21R)-21-hydroxy-20,21-dihydropuupehenone by extensive spectroscopic and computational methods. Compound 2 exhibited potent activity against Cryptococcus neoformans and Candida krusei with MFCs of 1… CONTINUE READING