Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases

  title={Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases},
  author={F. B. Young and S. Butland and S. Sanders and L. Sutton and M. Hayden},
  journal={Progress in Neurobiology},
  • F. B. Young, S. Butland, +2 authors M. Hayden
  • Published 2012
  • Biology, Medicine
  • Progress in Neurobiology
  • Post-translational modification of proteins by the lipid palmitate is critical for protein localization and function. Palmitoylation is regulated by the opposing enzymes palmitoyl acyltransferases (PATs) and acyl protein thioesterases, which add and remove palmitate from proteins, respectively. Palmitoylation is particularly important for a number of processes including neuronal development and synaptic activity in the central nervous system. Dysregulated palmitoylation contributes to… CONTINUE READING
    105 Citations
    Palmitoylation in Alzheimer's disease and other neurodegenerative diseases.
    • 48
    • PDF
    Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers
    • 63
    • PDF
    Protein S-palmitoylation and cancer.
    • 63
    Targeting protein palmitoylation: selective inhibitors and implications in disease
    • 34
    Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
    • 53
    • PDF


    Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL.
    • 97
    • PDF
    Huntingtin-Interacting Protein HIP14 Is a Palmitoyl Transferase Involved in Palmitoylation and Trafficking of Multiple Neuronal Proteins
    • 306
    Palmitoylation of huntingtin by HIP14is essential for its trafficking and function
    • 295
    Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
    • 67
    • PDF
    Huntingtin-interacting Proteins, HIP14 and HIP14L, Mediate Dual Functions, Palmitoyl Acyltransferase and Mg2+ Transport*
    • 75
    • PDF
    The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis.
    • J. Bellizzi, J. Widom, +4 authors J. Clardy
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 141
    • PDF
    Identification of PSD-95 Palmitoylating Enzymes
    • 436
    • Highly Influential