Putting p53 in Context

@article{Kastenhuber2017PuttingPI,
  title={Putting p53 in Context},
  author={Edward R Kastenhuber and S. Lowe},
  journal={Cell},
  year={2017},
  volume={170},
  pages={1062-1078}
}
  • Edward R Kastenhuber, S. Lowe
  • Published 2017
  • Biology, Medicine
  • Cell
  • TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative transcriptional program that touches upon a bewildering array of biological responses. Despite the many unveiled facets of the p53 network, a clear appreciation of how and in what contexts p53 exerts its diverse effects remains unclear. How can we interpret p53's disparate activities and the consequences of its… CONTINUE READING

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Control of metabolism by p53 – Cancer and beyond☆
    • 44
    • Open Access
    Regulation and function of p53: A perspective from Drosophila studies
    • 10
    • Open Access
    Transposons, p53 and Genome Security.
    • 9
    • Open Access
    Functional Diversity of p53 in Human and Wild Animals
    • 8
    • Open Access
    The p53 Pathway in Glioblastoma
    • 28
    • Open Access
    Mutant p53 in cancer therapy—the barrier or the path
    • 28
    • Open Access
    Inhibition of p53 inhibitors: progress, challenges and perspectives
    • 13
    • Highly Influenced
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 205 REFERENCES
    Mutant p53: one name, many proteins.
    • 760
    • Open Access
    In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
    • 3,530
    • Highly Influential
    • Open Access
    The p53 circuit board.
    • 82
    • Open Access
    Mdm2 promotes the rapid degradation of p53
    • 3,970
    p53 family in development
    • 55
    • Open Access
    Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
    • 864
    • Open Access
    WAF1, a potential mediator of p53 tumor suppression
    • 8,093
    • Open Access
    TP53 loss creates therapeutic vulnerability in colorectal cancer
    • 131
    • Open Access
    Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth
    • 181
    • Open Access
    IAPP driven metabolic reprogramming induces regression of p53 - deficient tumours in vivo
    • 94
    • Open Access