Putting p53 in Context

@article{Kastenhuber2017PuttingPI,
  title={Putting p53 in Context},
  author={Edward R. Kastenhuber and Scott W Lowe},
  journal={Cell},
  year={2017},
  volume={170},
  pages={1062-1078}
}
TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative transcriptional program that touches upon a bewildering array of biological responses. Despite the many unveiled facets of the p53 network, a clear appreciation of how and in what contexts p53 exerts its diverse effects remains unclear. How can we interpret p53's disparate activities and the consequences of its… CONTINUE READING
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