Putting an N-terminal end to the Clostridium thermocellum xylanase Xyn10B story: crystal structure of the CBM22-1-GH10 modules complexed with xylohexaose.

@article{Najmudin2010PuttingAN,
  title={Putting an N-terminal end to the Clostridium thermocellum xylanase Xyn10B story: crystal structure of the CBM22-1-GH10 modules complexed with xylohexaose.},
  author={Shabir Najmudin and Benedita A. Pinheiro and Jos{\'e} A M Prates and Harry J. Gilbert and Maria Jo{\~a}o Rom{\~a}o and Carlos M G A Fontes},
  journal={Journal of structural biology},
  year={2010},
  volume={172 3},
  pages={
          353-62
        }
}
In general, plant cell wall degrading enzymes are modular proteins containing catalytic domains linked to one or more non-catalytic carbohydrate-binding modules (CBMs). Xyn10B from Clostridium thermocellum is a typical modular enzyme containing an N-terminal family 22 CBM (CBM22-1), a family 10 glycoside hydrolase catalytic domain (GH10), a second CBM22 (CBM22-2), a dockerin sequence and a C-terminal family 1 carbohydrate esterase (CE1) catalytic domain. The structure of the N-terminal bi… CONTINUE READING

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