Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice.

@article{Zomkowski2006PutrescinePA,
  title={Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice.},
  author={Andr{\'e}a D.E. Zomkowski and Adair Roberto Soares dos Santos and Ana L{\'u}cia S Rodrigues},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2006},
  volume={30 8},
  pages={1419-25}
}
Putrescine, a polyamine present at high concentrations in the mammalian brain, was suggested to play a role in the modulation of depression. Thus, this study investigated the effect of putrescine in the mouse forced swimming test (FST) and in the tail suspension test (TST), two models predictive of antidepressant activity. Putrescine significantly reduced the immobility time both in the FST and in the TST (dose range of 1-10 mg/kg, i.p.), without changing locomotion in an open-field. I.c.v… CONTINUE READING

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