Putrescine decreases cytochrome P450 3A4 levels during liver regeneration in the rat.


BACKGROUND/AIMS The mechanism by which many cytochrome P450 (CYP) isozymes decrease during liver regeneration is unclear. Peptides and growth factors are thought to be involved. Putrescine, the first polyamine synthesised by ornithine decarboxylase, peaks early following partial hepatectomy and is known to play an essential role in hepatic regeneration… (More)