Putrescine and spermidine transport in Leishmania.

  title={Putrescine and spermidine transport in Leishmania.},
  author={Mireille Basselin and Graham H. Coombs and Michael P. Barrett},
  journal={Molecular and biochemical parasitology},
  volume={109 1},
The transport of putrescine and spermidine into Leishmnania donovani promastigotes and Leishmania mexicana promastigotes and amastigotes has been characterised. Polyamine transport was shown to be saturable and temperature-sensitive for both developmental stages of Leishmania. Transport was pH-dependent with pH optima of 7.4 and 5.5 for promastigotes and amastigotes, respectively. The uptake process was independent of extracellular Na+, but inhibited by protonophores and H+-ATPase inhibitors… CONTINUE READING