Putatively Functional PLCE1 Variants and Susceptibility to Esophageal Squamous Cell Carcinoma (ESCC): A Case–Control Study in Eastern Chinese Populations

@article{Hu2011PutativelyFP,
  title={Putatively Functional PLCE1 Variants and Susceptibility to Esophageal Squamous Cell Carcinoma (ESCC): A Case–Control Study in Eastern Chinese Populations},
  author={Haichuan Hu and Jingmin Yang and Yihua Sun and Ya-jun Yang and J. Qian and L. Jin and M. Wang and R. Bi and Ruoxin Zhang and Meiling Zhu and Menghong Sun and H. Ma and Q. Wei and Guoliang Jiang and Xiaoyang Zhou and Haiquan Chen},
  journal={Annals of Surgical Oncology},
  year={2011},
  volume={19},
  pages={2403-2410}
}
BackgroundA novel variant rs2274223 located in the phospholipase C epsilon 1 (PLCE1) gene was found to be associated with risk of esophageal squamous cell carcinoma (ESCC) by 2 large-scale genome-wide association studies (GWASs) in Chinese populations. In this study, we aimed to assess such an association in an eastern Chinese population and to address its possibly functional role in the etiology of ESCC.MethodsA total of 1061 ESCC cases and 1211 controls were recruited and successfully… Expand
Two novel polymorphisms in PLCE1 are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population.
  • Y. Qu, S. Zhang, +5 authors L. Dai
  • Medicine
  • Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • 2017
PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population
Phospholipase C ε-1 gene polymorphisms and prognosis of esophageal cancer patients from a high-incidence region in northern China.
Functional role of PLCE1 intronic insertion variant associated with susceptibility to esophageal squamous cell carcinoma
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