Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans.

  title={Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans.},
  author={Harmit Singh Malik and William D. Burke and Thomas H. Eickbush},
  volume={251 2},
Eukaryotic chromosomes end in short nucleotide repeats that are added by the enzyme telomerase. The catalytic subunit of telomerase has been shown to be most closely related in sequence to reverse transcriptases encoded by eukaryotic retrotransposable elements. This raises the question as to whether the telomerase subunit was present in the first eukaryotes or was derived during early eukaryote evolution from the replication machinery of a retrotransposable element. We present the sequence of a… CONTINUE READING


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