Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area.

@article{Schilstrm2000PutativeRO,
  title={Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area.},
  author={Bj{\"o}rn Schilstr{\"o}m and M. V. Fagerquist and Xuying Zhang and Peter Hertel and George Panagis and George G. Nomikos and Torgny H. Svensson},
  journal={Synapse},
  year={2000},
  volume={38 4},
  pages={375-83}
}
We have previously provided evidence that the stimulatory action of systemic nicotine on dopamine release in the rat nucleus accumbens is initiated in the ventral tegmental area (VTA), and that it appears to be mediated partly through an indirect, presynaptic mechanism. Thus, it was found that blockade of N-methyl-D-aspartate (NMDA) receptors in the VTA attenuates the enhancing effect of nicotine on extracellular levels of dopamine in the nucleus accumbens. Moreover, the nicotine-induced… CONTINUE READING

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